Another surprise from Gargamelle

Split Genes: Another Surprise from Giardia

Some genes in the candidate early-branching eukaryote Giardia lamblia occur in separate pieces, transcribed from non-contiguous chromosomal locations. The pre-mRNAs from the separate pieces apparently find each other by regions of complementarity and are subsequently spliced together by the spliceosome. Could genes in pieces, transcribed into separate pre-mRNAs, have been an early feature of sp...

Surprise, Surprise from Neoclassical Economics to E-life2

We build and describe an agent-based model: the Surprise Game. The game comprises a “world” of 30 fi rms, each of which has to survive (and, if possible, prosper) in its environment, which is nothing more than the other 29 fi rms. Each fi rm has to latch onto one or other of the four strategies that are predicted by the theory of plural rationality but has to relinquish that strategy and latch ...

A study on the definitions of religion from another view

Cancer Therapeutics Insights Another Surprise from Metformin: Novel Mechanism of Action via K-Ras Influences Endometrial Cancer Response to Therapy

Metformin is an oral biguanide commonly used for the treatment of type II diabetes and has recently been demonstrated to possess antiproliferative properties that can be exploited for the prevention and treatment of a variety of cancers. The mechanisms underlying this effect have not been fully elucidated. Using both in vitro and in vivomodels, we examined the effects of metformin on endometria...

Another surprise from Metformin: novel mechanism of action via K-Ras influences endometrial cancer response to therapy.

Metformin is an oral biguanide commonly used for the treatment of type II diabetes and has recently been demonstrated to possess antiproliferative properties that can be exploited for the prevention and treatment of a variety of cancers. The mechanisms underlying this effect have not been fully elucidated. Using both in vitro and in vivo models, we examined the effects of metformin on endometri...